Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation
Andreas Postlmayr, Astrid Sanchez Bergman, Jacob Torrejon-Diaz, Bernard Ciraulo, Shen Yan, Nina Hofmann, Samanta Kisele, Rosalie Dobler, Charbel Machaalani, Marc Thomas Schönholzer, Laura Priego-González, Andrea Joseph De Micheli, Ernesto Berenjeno‐Correa, Luca Baroncini, Michael Andreas Grotzer, , Ana Guerreiro Stücklin
The paper identifies functionally distinct ALK and ROS1 fusions in infant-type hemispheric gliomas, showing they converge on STAT3 and SHP2 activation through different mechanisms.
Cell Reports · Mar 1, 2026Peer-reviewedCancer Biology