Disordered N-terminal region of CLK1 oligomerizes for recruitment to nuclear substructures and splicing function
Athira George, Laurent Fattet, Dominique T. Capraro, Patricia Ann Jennings, Joseph A. Adams
The paper shows that the disordered N-terminal region of CLK1 is required for oligomerization and nuclear localization, which is essential for splicing function but not for phosphorylation of SR proteins.
bioRxiv · Feb 23, 2026 · PreprintBiochemistry