Cancer BiologyNature CommunicationsPeer-reviewed
Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction
Zhimin Hu, Hannah E. Majeski, Aida Mestre‐Farrera…·Jane Yang
This study shows that TYK2 suppresses breast cancer metastasis under low ECM stiffness by promoting EMT, and its localization changes with ECM rigidity.