Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN
Masahiro Nogami, Mitsuru Ishikawa, Atsushi Doi, Osamu Sano, Takefumi Sone, Tetsuya Akiyama, Masashi Aoki, Atsushi Nakanishi, Kazuhiro Ogi, Masato Yano, Hideyuki Okano
The paper uses iBRN to identify hub molecules in FUS-ALS, finding miR-125b-5p-TIMELESS and PRKDC as key regulators of DNA repair and stress granule formation.
Neurobiology of Disease · Apr 20, 2021Peer-reviewedNeuroscience