Masashi Aoki

ALS-associated RNA binding proteins converge on UNC13A transcription through regulation of REST

The paper shows that three ALS-associated RBPs regulate UNC13A transcription by targeting REST, highlighting their role in synaptic integrity and ALS pathogenesis.

tRNA modifications inform tissue specific mRNA translation and codon optimization.

The paper shows that tRNA modifications influence tissue-specific mRNA translation and codon optimization by analyzing tRNA and mRNA data from seven mouse tissues.

Genome-wide association study identifies a new susceptibility locus in PLA2G4C for Multiple System Atrophy.

This study identifies a new susceptibility locus, PLA2G4C, for Multiple System Atrophy through a genome-wide association study and functional analysis of a risk variant.

Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN

The paper uses iBRN to identify hub molecules in FUS-ALS, finding miR-125b-5p-TIMELESS and PRKDC as key regulators of DNA repair and stress granule formation.

Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5

This study identifies mitochondrial dysfunction in sporadic inclusion body myositis and shows that MA-5 improves mitochondrial function and protects myoblasts.