Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro
Mikhail A. Hameedi, Erica Teixeira Prates, Michael R. Garvin, Irimpan I. Mathews, B Kirtley Amos, Omar Demerdash, Mark Bechthold, Mamta Iyer, Simin Rahighi, Daniel W. Kneller, Andrey Y. Kovalevsky, Stephan Irle, Van‐Quan Vuong, Julie C. Mitchell, Audrey D. Labbe, , Daniel Jacobson
This study characterizes how SARS-CoV-2 3CLpro cleaves NEMO, revealing structural and functional insights that explain its high fitness in humans.
Nature Communications · Sep 8, 2022Peer-reviewedMolecular Biology