Irimpan I. Mathews

The paper introduces mCranberry, a bright monomeric red fluorescent protein with 85% quantum yield, engineered through surface-mutation-guided strategies.

This paper introduces dEVA, a framework for de novo metalloenzyme design, achieving high catalytic activity without natural templates.

The paper presents the first dimeric ECR structure from Mesorhizobium metallidurans, revealing structural differences that may impact catalytic activity compared to tetrameric ECRs.

This paper introduces Caliby, a sequence design method that conditions on structural ensembles to improve designability while reducing native sequence recovery.

This paper develops a mid-IR quantum cascade laser spectroscopy method to detect drug-target interactions in live cells using photoactive yellow protein as a model system.

This study characterizes how SARS-CoV-2 3CLpro cleaves NEMO, revealing structural and functional insights that explain its high fitness in humans.

This paper designs protein sequences using a deep neural network trained on crystal structures, producing stable designs that match high-resolution structures.