Author

Daniel W. Kneller

Oak Ridge National LaboratoryORCID 0000-0002-5416-5789Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrey Y. KovalevskyiD· 2 shared Alice R. WalkeriD· 1 shared Audrey D. Labbe· 1 shared B Kirtley AmosiD· 1 shared Dai Nan· 1 shared Daniel JacobsoniD· 1 shared Erica Teixeira PratesiD· 1 shared Irimpan I. MathewsiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

Andrey Y. KovalevskyORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 23, 2026

Cap-specific N6-adenosine methyltransferases and applications in m6A Cap-1 mRNA synthesis

Daniel W. Kneller, Dai Nan, Siu‐Hong Chan

This study identifies and characterizes PC04 and PC05, two cap-specific N6-adenosine methyltransferases, and demonstrates their use in synthesizing m6A Cap-1 mRNA in vitro.

DOI 10.64898/2026.10.22.757692

experimental assayprotein design

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BiochemistryBiochemistryPeer-reviewedFeb 9, 2026

Environmental Contributions to Proton Sharing in Protein Low-Barrier Hydrogen Bonds

Jiusheng Lin, Oksana O. Gerlits, Daniel W. Kneller…·Mark A. Wilson

This study uses neutron crystallography and simulations to analyze proton sharing in low-barrier hydrogen bonds in DJ-1 and YajL, showing how mutations affect proton delocalization and mobility.

1 citation

humanbacteria (other)

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Molecular BiologyNature CommunicationsPeer-reviewedSep 8, 2022

Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro

Mikhail A. Hameedi, Erica Teixeira Prates, Michael R. Garvin…·Daniel Jacobson

This study characterizes how SARS-CoV-2 3CLpro cleaves NEMO, revealing structural and functional insights that explain its high fitness in humans.

32 citations

humanmachine learning (classical)

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