In vitro and in vivo activity profiles of broad-spectrum bacterial ATP synthase inhibitors
Suzanne Chamberland, Audrey Larose, Guillaume Millette, Jean-Philippe Langlois, Julie Côté-Gravel, Éric Brouillette, Daniela Droppa‐Almeida, Renaud Binette, Julien A. Delbrouck, Iryna Diachenko, Abdelkhalek Ben Jamaa, Chad Normandin, Alexandre Murza, François Malouin, Pierre‐Luc Boudreault
The paper evaluates the antibacterial activity of tomatidine analogs against various bacterial strains, identifying TM-184 as effective against Gram-positive, Gram-negative, and multidrug-resistant bacteria, with in vivo efficacy in a mouse model.
Bioorganic & Medicinal Chemistry · Nov 21, 2025Peer-reviewedMolecular Biology