Unlocking Sensitive Data with SPHERE in the Age of AI
Zihuai He, Jun Young Park, Rafael Catoia Pulgrossi, Justin Lee, Robert R. Butler, Audrey Weber, Lü Tian, Xiang Zhang, Julie (Fangran) Wang, Sharon J. Sha, Elizabeth C. Mormino, Tony Wyss‐Coray, Victor W. Henderson, Frank M. Longo, James Zou, , Russ Biagio Altman
SPHERE enables the use of sensitive datasets in AI and open science by creating synthetic twins that preserve statistical properties and privacy.
bioRxiv · Sep 17, 2026 · PreprintBioinformatics