Lü Tian

Unlocking Sensitive Data with SPHERE in the Age of AI

SPHERE enables the use of sensitive datasets in AI and open science by creating synthetic twins that preserve statistical properties and privacy.

Multi-Sample and Multi-Group Spatial Colocalization Analysis Using PANORAMIC

PANORAMIC improves spatial colocalization analysis by accounting for within-sample uncertainty, revealing stronger immune cell colocalization in specific colorectal cancer subtypes.

An in silico framework for evaluating PRS-guided prognostic enrichment in clinical trial design

This paper develops an in silico framework to evaluate the impact of polygenic risk score (PRS)-guided prognostic enrichment on clinical trial design using genomic and electronic health record data.

Aging trajectories of memory CD8+ T cells differ by their antigen specificity

The paper examines how aging affects antigen-specific memory CD8+ T cells in EBV infection, finding distinct aging trajectories with changes in gene expression and TCR diversity.

Spatial Profiling Reveals Equivalence-Derived Molecular Signatures of Brain Mimicry and Adaptation in Breast Cancer Brain Metastases

This study identifies molecular signatures of brain mimicry and adaptation in breast cancer brain metastases using spatial transcriptomic profiling and a new algorithm called Equivalent Expression Index.

Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia

This study identifies changes in pregnancy-related serum biomarkers early in gestation as indicators of later preeclampsia development, validated in both human and mouse models.

CSF sTREM2 correlates with CSF tau in advancing Parkinson’s disease

The paper examines the correlation between CSF sTREM2 and CSF tau levels in Parkinson’s disease and finds that sTREM2 is elevated in PD subgroups with abnormal tau but not Aβ.