Frank M. Longo

SPHERE enables the use of sensitive datasets in AI and open science by creating synthetic twins that preserve statistical properties and privacy.

This paper introduces a framework for identifying disease-associated features tailored to individual profiles using localized test statistics, applied to single-cell RNA sequencing data for Alzheimer's disease.

The paper identifies cross-domain drivers of Alzheimer's disease risk by integrating network analysis across biological domains.

This study identifies sex-specific changes in bone and senescence-related proteins in neurodegenerative diseases using plasma proteomics.

This study shows that p75NTR upregulation after perinatal hypoxia impairs PV GABAergic cell maturation and leads to cognitive deficits in adult mice, which can be reversed by p75NTR inhibition.

This study shows that human striatal progenitor cells overexpressing BDNF and with inducible safety switches improve HD symptoms in R6/2 mice.

This study shows that inhibiting IDO1 restores hippocampal glucose metabolism and rescues cognition in Alzheimer's disease models.

This study shows that the small-molecule TrkB agonist LM22A-4 improves dendritic spine morphology and reduces aggressive behaviors in female Rett syndrome mice.

BD10-2, a TrkB/C partial agonist, improves memory and LTP deficits in Alzheimer's mice by modulating synaptic signaling and microglial transcriptomic changes.

This study shows that Bmal1 deficiency in myeloid cells disrupts microglial synaptic pruning, accelerates cognitive aging, and affects sleep-wake cycles in mice.

This study shows that LM11A-31, a p75NTR modulator, improves stroke recovery by enhancing brain metabolism, neurotransmitter levels, and reducing neurodegeneration in mice.

This study shows that LM11A-31 treatment improves neurocognitive performance in FIV-infected cats without adverse effects.

The paper examines the correlation between CSF sTREM2 and CSF tau levels in Parkinson’s disease and finds that sTREM2 is elevated in PD subgroups with abnormal tau but not Aβ.