Systematic tissue oxygen variation shows the modulation of murine skin radiation toxicity at ultra-high dose rates
David I. Hunter, Jacob P. Sunnerberg, Armin D. Tavakkoli, Austin M. Sloop, Beverly Petusseau, Jiang Gui, Xu Cao, Rongxiao Zhang, Simin Belali, Harold M. Swartz, Lesley A. Jarvis, Paul Jack Hoopes, D.J. Gladstone, Brian W. Pogue
This study shows that moderate and low tissue oxygen levels reduce radiation toxicity in murine skin under ultra-high dose rates but not conventional rates, with no FLASH sparing under anoxia or hyperoxia.
Physics in Medicine and Biology · Apr 24, 2026Peer-reviewedCancer Biology