Brian W. Pogue

This study shows that moderate and low tissue oxygen levels reduce radiation toxicity in murine skin under ultra-high dose rates but not conventional rates, with no FLASH sparing under anoxia or hyperoxia.

This study shows that anesthesia type affects the effectiveness of ultra-high dose-rate FLASH irradiation in sparing normal tissue in mice, with ketamine/xylazine preserving sparing while isoflurane abolishes it.

This paper visualizes lymphatic dynamics using transient hypoxia imaging in mice, showing hypoxia in lymph nodes and altered pumping frequency with tissue damage.