Juvenile and adult expression of polyglutamine expanded huntingtin produce distinct aggregate distributions in Drosophila muscle
Taylor Barwell, Sehaj Raina, Austin Page, Hayley MacCharles, Laurent Seroude
This study expresses a pathogenic HD construct in Drosophila muscle and finds distinct aggregate distributions and phenotypes depending on expression timing and level.
Human Molecular Genetics · Jun 23, 2023Peer-reviewedGenetics