Laurent Seroude

EDTP Loss of Function Impairs Longevity and Reproduction

This study shows that EDTP loss of function in Drosophila reduces reproduction and lifespan, with effects restricted to developmental and adult stages.

Juvenile and adult expression of polyglutamine expanded huntingtin produce distinct aggregate distributions in Drosophila muscle

This study expresses a pathogenic HD construct in Drosophila muscle and finds distinct aggregate distributions and phenotypes depending on expression timing and level.

Expression of heat shock protein 70 is insufficient to extend Drosophila melanogaster longevity

This study shows that overexpressing hsp70 in Drosophila melanogaster does not extend longevity or stress resistance, except for a reduction in male lifespan with ubiquitous expression.

Regulating the UAS/GAL4 system in adult Drosophila with Tet-off GAL80 transgenes

This study constructs and characterizes Tet-off GAL80 transgenes to enable temporal control of GAL4 activity in adult Drosophila, showing age and sex-dependent effects on repression.

Tissue-specific downregulation of EDTP suppresses polyglutamine protein aggregates and extends lifespan in Drosophila

This study shows that reducing EDTP in specific Drosophila tissues reduces polyglutamine aggregates and extends lifespan.