A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter SLC43A1 (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells
Nisha R. Pawar, HM Wade, Zoè Jackson, N Poungpeth, AV Mitchell, CP Jewell, Dalen Chan, Robert W. Robey, Pedro J. Batista, Lauren M. Jenkins, Michael M. Gottesman
The paper identifies SLC43A1 (LAT3) as a key determinant of oxaliplatin sensitivity in colorectal cancer cells through CRISPR screens and functional validation.
Molecular Cancer Therapeutics · Jun 2, 2026Peer-reviewedCancer Biology