The ortholog of the Human T2D Risk Gene STEAP2 is Required for Glucose Stimulated Insulin Secretion in Mice
Avery Hawthorne, Kai Kelly, Mark Tigue, Hilana El‐Mekkoussi, Eric L. Waite, Yelda Erhan, Elisabetta Manduchi, Sepideh Dashti, Andrea Rozzo, Jeffrey Roman, Nicolai M. Doliba, Doris A. Stoffers, Klaus H. Kaestner
This study shows that Steap2 is essential for glucose-stimulated insulin secretion in mice by maintaining mitochondrial function in pancreatic beta-cells.
bioRxiv · Oct 2, 2026 · PreprintGenetics