Author

Hilana El‐Mekkoussi

University of PennsylvaniaORCID 0000-0001-5561-4358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetics· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Elisabetta ManduchiiD· 3 shared Klaus H. KaestneriD· 3 shared Ali NajiiD· 2 shared Chengyang LiuiD· 2 shared Deeksha Lahori· 2 shared Hélène C. DescampsiD· 2 shared Jonathan SchugiD· 2 shared Tong DaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenetics

Elisabetta ManduchiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

GeneticsbioRxivPreprintOct 2, 2026

The ortholog of the Human T2D Risk Gene STEAP2 is Required for Glucose Stimulated Insulin Secretion in Mice

Avery Hawthorne, Kai Kelly, Mark Tigue…·Klaus H. Kaestner

This study shows that Steap2 is essential for glucose-stimulated insulin secretion in mice by maintaining mitochondrial function in pancreatic beta-cells.

DOI 10.64898/2026.09.26.754731

mouseexperimental assay

𝕏 PostBluesky

GenomicsbioRxivPreprintJul 2, 2025

Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes

Elisabetta Manduchi, Hélène C. Descamps, Jinping Liu…·Dana Avrahami

The paper examines age-related DNA methylation changes in beta and alpha cells using HPAP data, finding accelerated demethylation in T2D beta cells.

1 citation

humanDNA methylation

𝕏 PostBluesky

Systems BiologybioRxivPreprintFeb 14, 2025

Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas

Michelle Y. Y. Lee, Omar Guessoum, Hilana El‐Mekkoussi…·Klaus H. Kaestner

The paper identifies transitional cell states between alpha and beta cells in human islets using single-cell multiome data, suggesting potential for alpha-to-beta transdifferentiation.

2 citations

humanscRNA-seq

𝕏 PostBluesky