Author

Mark Tigue

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 1

Frequent Co-Authors

Klaus H. KaestneriD· 3 shared Catherine Lee May· 2 shared Elisabetta ManduchiiD· 2 shared Andrea Rozzo· 1 shared Ashleigh R. Morgan· 1 shared Avery Hawthorne· 1 shared Benjamin F. VoightiD· 1 shared Benjamin GläseriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenetics

Klaus H. KaestnerORCID

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3 papers

Recent·Most cited

The ortholog of the Human T2D Risk Gene STEAP2 is Required for Glucose Stimulated Insulin Secretion in Mice

Avery Hawthorne, Kai Kelly, Mark Tigue, Hilana El‐Mekkoussi, Eric L. Waite, Yelda Erhan, Elisabetta Manduchi, Sepideh Dashti, Andrea Rozzo, Jeffrey Roman, Nicolai M. Doliba, Doris A. Stoffers, Klaus H. Kaestner

This study shows that Steap2 is essential for glucose-stimulated insulin secretion in mice by maintaining mitochondrial function in pancreatic beta-cells.

bioRxiv · Oct 2, 2026 · PreprintGenetics

G6PC2 controls glucagon secretion by defining the setpoint for glucose in pancreatic α-cells

Varun Bahl, Eric Waite, Reut Rifkind, Zenab Hamdan, Catherine Lee May, Elisabetta Manduchi, Benjamin F. Voight, Michelle Y. Y. Lee, Mark Tigue, Nicholas Manuto, Benjamin Gläser, Dana Avrahami, Klaus H. Kaestner

This study identifies G6PC2's role in regulating glucagon secretion in α-cells, showing it controls glucose setpoint and suggests G6PC2 inhibitors could improve glycemic control.

Science Translational Medicine · Jan 1, 2025Peer-reviewedGenetics

Telomouse - a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

Riham Smoom, Catherine Lee May, Vivian Ortiz, Mark Tigue, Hannah M. Kolev, Melissa M. Rowe, Yitzhak Reizel, Ashleigh R. Morgan, Nachshon Egyes, Dan Lichtental, Emmanuel Skordalakes, Klaus H. Kaestner, Yehuda Tzfati

This paper introduces a mouse model with human-length telomeres by modifying RTEL1 and shows its impact on regenerative capacity.

Nature Communications · Oct 23, 2023Peer-reviewedGenetics