Regulation of CHD2 expression by the Chaserr long noncoding RNA is essential for viability
Aviv Rom, Liliya Melamed, Noa Gil, Micah Jonathan Goldrich, Rotem Kadir, Matan Golan, Inbal Eti Biton, Rotem Ben‐Tov Perry, Igor Ulitsky
This study shows that the lncRNA Chaserr regulates Chd2 expression, and its loss causes lethality and growth defects in mice by increasing Chd2 levels and transcriptional interference.
Nature Communications · Nov 8, 2019Peer-reviewedMolecular Biology