Noa Gil

This paper introduces a deep learning framework to quantify chromatin sensitivity of transcription factors, revealing a continuum of sensitivity rather than distinct hierarchical or cooperative mechanisms.

The paper identifies a genetic circuitry where OCT4 activates an antisense lncRNA that represses Suv39h1, linking H3K9 methylation levels to pluripotency in mouse ES cells.

The paper functionally annotates human long non-coding RNAs by systematically knocking down 285 lncRNAs and analyzing molecular phenotypes using CAGE sequencing.

This study shows that the lncRNA Chaserr regulates Chd2 expression, and its loss causes lethality and growth defects in mice by increasing Chd2 levels and transcriptional interference.

The paper investigates the relationship between spliced long noncoding RNAs (lncRNAs) and enhancer activity, finding that lncRNA production enhances enhancer function through conserved splicing signals.

The paper identifies NORAD, a conserved cytoplasmic lncRNA, and shows it modulates PUM1 and PUM2 to regulate mRNA levels of genes involved in chromosome segregation.