Spatial mapping of proteins and their activity states in cancer models by multiplex in situ PLA
Liza Löf, Bo Xu, Tanay Kumar Sinha, Caroline Dahlström, Jonas Vennberg, Tore Larsson Forssén, Axel Klaesson, Carl-Magnus Clausson, Xuan Wang, Ulla Strömberg-Olsson, Masood Kamali‐Moghaddam, Christophe Avenel, Carolina Wählby, Agata Zieba-Wicher, Ulf D. Landegren
This paper introduces misPLA, a method for spatially mapping protein interactions and activity states in cancer models, revealing shared and disease-specific signaling patterns.
bioRxiv · Jul 11, 2025 · PreprintMolecular Biology