This paper introduces misPLA, a method for spatially mapping protein interactions and activity states in cancer models, revealing shared and disease-specific signaling patterns.

bioRxiv · Jul 11, 2025 · PreprintMolecular Biology

Pharmacogenomics of GLP-1 Receptor Agonists: A genome-wide analysis of observational data and large randomized controlled trials

Adem Y. Dawed, Andrea Mari, Andrew Anand Brown, Timothy James McDonald, Lin Li, Shuaicheng Wang, Mun‐Gwan Hong, Sapna Sharma, Neil R. Robertson, Anubha Mahajan, Xuan Wang, Mark Walker, Stephen Charles Langford Gough, Leen M. ‘t Hart, Kaixin Zhou, , A. Jonsson

This study identifies genetic variants associated with glycaemic response to GLP-1 receptor agonists using observational and trial data, finding variants in GLP-1R and ARRB1 linked to HbA1c reduction.

The Lancet Diabetes & Endocrinology · Dec 15, 2022Peer-reviewedGenetic & Genomic Medicine

Dissection of the cellular function of the ZBED6 transcription factor in mouse myoblast cells using gene editing, RNAseq and proteomics

Shady Younis, Rakan Naboulsi, Xuan Wang, Xiaofang Cao, Mårten Larsson, Ernest Sargsyan, Peter Bergsten, Nils Welsh, Leif Andersson

This study investigates ZBED6's role in mouse myoblasts using gene editing, RNAseq, and proteomics, showing ZBED6 regulates IGF2 through a specific binding site, affecting mitochondrial activity and myogenesis.

bioRxiv · Feb 5, 2019 · PreprintMolecular Biology