A transgenic mutant mouse line accompanied by the complete deletion of interleukin-33 showed insulin and leptin resistances
Taku Watanabe, Tomonori Takeuchi, Naoto Kubota, Tasuku Wainai, Keisuke Kataoka, Toshitaka Nakaya, Ayako Sugimoto, Takahiro Sato, Hiroshi Ohira, Ichizo Tsujino, Katsuyoshi Kumagai, Tetsuya Kubota, Chiaki Hasegawa, Kumpei Tokuyama, Kohjiro Ueki, , Takashi Kadowaki
The paper shows that deletion of the Il33 gene in mice leads to insulin and leptin resistance, with improved insulin sensitivity upon IL-33 supplementation.
bioRxiv · Sep 13, 2018 · PreprintMolecular Biology