Naoto Kubota

Gut-derived GLP-1 released by rare sugar D-allulose cooperates with insulin to activate left-sided vagal afferents and enhance insulin sensitivity

This paper shows that D-allulose-induced GLP-1 enhances insulin action via left-sided vagal afferents, improving glucose tolerance more effectively than GLP-1 receptor agonists in mice.

A transgenic mutant mouse line accompanied by the complete deletion of interleukin-33 showed insulin and leptin resistances

The paper shows that deletion of the Il33 gene in mice leads to insulin and leptin resistance, with improved insulin sensitivity upon IL-33 supplementation.