Paused Polymerase synergises with transcription factors and RNA to enhance the transcriptional potential of promoters
Rajat Mann, Deepanshu Soota, Ayan Das, Nitesh Kumar Podh, Gunjan Mehta, Dimple Notani
The paper shows that paused RNA polymerase II enhances transcription factor binding through RNA-dependent mechanisms, leading to stronger transcriptional activation upon release.
bioRxiv · Oct 18, 2024 · PreprintMolecular Biology