Capillary constrictions prime cancer cell tumorigenicity through PIEZO1
Giulia Silvani, Chantal Kopecky, Sara Romanazzo, Vanina Rodríguez, Ayan Das, Elvis Pandžić, John George Lock, Christine Louise Chaffer, Kate Poole, Kristopher Alan Kilian
This study shows that capillary constrictions reprogram melanoma cells to a tumorigenic cancer stem cell-like state via PIEZO1 mechanosensing.
Nature Communications · Sep 1, 2025Peer-reviewedCancer Biology