Deepanshu Soota

Enhancers require an active resetting phase after transcriptional activation

The paper identifies AR as the factor driving active enhancer resetting after transcriptional activation, which prevents transcriptional hyperactivation in ER-positive breast cancer.

A Cellular Basis for Heightened Gut Sensitivity in Females

The paper identifies an estrogen-responsive paracrine pathway in the gut that increases sensitivity in females by enhancing communication between enteroendocrine cells and sensory nerves.

Nuclear myosin I mediates genomic clustering of estrogen receptor-α without affecting ligand-induced transcriptional robustness

The paper identifies nuclear myosin I as a regulator of estrogen receptor-α clustering on enhancers, showing that this clustering is not essential for robust transcriptional responses to estrogen.

Paused Polymerase synergises with transcription factors and RNA to enhance the transcriptional potential of promoters

The paper shows that paused RNA polymerase II enhances transcription factor binding through RNA-dependent mechanisms, leading to stronger transcriptional activation upon release.

RNA binding limits the ligand induced transcriptional potential of estrogen receptor-alpha

This study shows that RNA binding enhances estrogen receptor-alpha (ER) chromatin binding, which limits its transcriptional activation in response to estrogen.

Discovery of tREP-18, a novel class of tRNA encoded peptide with potent leishmanicidal activity

The paper reports a novel tRNA-derived peptide, tREP-18, with potent anti-leishmanial activity against L. donovani and PKDL isolates.

Ligand dependent gene regulation by transient ERα clustered enhancers

The paper shows that unliganded ERα pre-marks enhancer sites, which form 3D clusters upon ligand exposure, driving transient gene expression.