Structure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies
Ezra T. Bekkering, Randy Yoo, Sophia Hailemariam, Fabian Heide, Danton Ivanochko, Matthew J. Jackman, Nicholas I. Proellochs, Rianne Stoter, Geert-Jan van Gemert, Ayana Maeda, Takaaki Yuguchi, Oscar T. Wanders, Renate C. van Daalen, Maartje R. Inklaar, Carolina M. Andrade, , Jean‐Philippe Julien
The paper determines the structure of the Pfs230:Pfs48/45 complex bound to transmission-blocking antibodies, revealing molecular interactions and epitopes that inform vaccine development.
bioRxiv · Feb 14, 2025 · PreprintMolecular Biology