Molecular BiologybioRxivPreprint
RNA and FUS act in concert to prevent TDP-43 spatial segregation
Clément Demongin, S. Tranier, Vandana Joshi…·Loïc Hamon
The paper shows that FUS and TDP-43 interact in mRNA-rich compartments, with FUS enabling TDP-43 to mix and prevent aggregation, and that this interaction is disrupted by pathological mutations.
DOI 10.1101/2023.07.25.550456