Author

David Pastré

InsermORCID 0000-0002-3348-9514Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Loïc HamoniD· 2 shared Mikhail M. KutuzoviD· 2 shared Olga I. LavrikiD· 2 shared Alexey A. MalyginiD· 1 shared Anastasia S. Singatulina· 1 shared Andrey S. Krasnikov· 1 shared Bénédicte Desforges· 1 shared Clément Demongin· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMolecular Biology

Loïc HamonORCID

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Author profile →

4 papers

Recent·Most cited

HPF1 REGULATES THE FORMATION OF FUS-DEPENDENT COMPARTMENTS BY PARP1 AND PARP2 ACTIVATION ON DAMAGED DNA

Anastasia S. Singatulina, Maria V. Sukhanova, Loïc Hamon, Mikhail M. Kutuzov, David Pastré, Olga I. Lavrik

This study investigates how HPF1 modulates PARP1 and PARP2 activity to influence FUS-dependent compartment formation during DNA damage.

Nucleic Acids Research · Feb 19, 2026Peer-reviewedMolecular Biology

Interplay between human ribosomal proteins, PARP1, PARP2, HPF1 and histones

Andrey S. Krasnikov, Konstantin N. Naumenko, Mikhail M. Kutuzov, Yulia B. Zhakupova, Maxim O. Pavlov, Alexey A. Malygin, David Pastré, D. M. Graifer, Olga I. Lavrik

The paper investigates ADP-ribosylation of human ribosomal proteins by PARP1 and PARP2, showing that 60S subunit RPs are more modified and HPF1 enhances this modification, while core histones compete with RPs for PARylation.

bioRxiv · Sep 15, 2025 · PreprintMolecular Biology

RNA and FUS act in concert to prevent TDP-43 spatial segregation

Clément Demongin, S. Tranier, Vandana Joshi, Léa Ceschi, Bénédicte Desforges, David Pastré, Loïc Hamon

The paper shows that FUS and TDP-43 interact in mRNA-rich compartments, with FUS enabling TDP-43 to mix and prevent aggregation, and that this interaction is disrupted by pathological mutations.

bioRxiv · Jul 25, 2023 · PreprintMolecular Biology

A complex view of GPCR signal transduction: Molecular dynamics of the histamine H3 membrane receptor

Leonardo David Herrera-Zúñiga, Liliana Marisol Moreno‐Vargas, Luck Ballaud, José Correa‐Basurto, Diego Prada‐Gracia, David Pastré, Patrick A. Curmi, Jean‐Michel Arrang, Rachid C. Maroun

This study uses molecular dynamics simulations to analyze structural and dynamical differences in the histamine H3 receptor across three states: apo, antagonist-bound, and agonist-bound.

bioRxiv · Jan 7, 2020 · PreprintBioinformatics