Obtusaquinone is a cysteine modifying compound that targets Keap1 for degradation
c. E. badr, C. C. da Hora, A. Kirov, R. Amante, E. Fitzsimons, J. W. Chen, A. E. Nibbs, I. Nakano, E. Tabet, N. Chiu, W. Haas, R. Mazitschek, B. A. Tannous
This study identifies Obtusaquinone as a cysteine-modifying compound that targets Keap1 for degradation, activating the Nrf2 pathway through proteasomal degradation.
ACS Chemical Biology · Apr 27, 2020Peer-reviewedCancer Biology