Joint antibiotic and phage therapy: addressing the limitations of a seemingly ideal phage for treating Staphylococcus aureus infections
B. Berryhill, D. Huseby, I. C. McCall, D. Hughes, B. R. Levin
This study evaluates the effectiveness of the phage PYOSa for treating Staphylococcus aureus infections, finding that while it has desirable traits, it fails to eliminate bacterial populations due to small colony variants, which can be mitigated by combining it with bactericidal antibiotics.
bioRxiv · Apr 24, 2020 · PreprintMicrobiology