D. Hughes

Apramycin efficacy in the treatment of carbapenem-resistant Enterobacterales in murine blood stream infection models

This study evaluates apramycin's efficacy against carbapenem-resistant Enterobacterales in mouse models, finding it effective against resistant isolates with high in vivo activity.

A new antibiotic from an uncultured bacterium binds to an immutable target

This paper discovers a new antibiotic, clovibactin, from uncultured bacteria that targets pyrophosphate in bacterial cell wall precursors, effectively killing drug-resistant pathogens without resistance.

An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity

This study identifies a circadian rhythm that regulates antiviral immunity in skin, showing that aging disrupts this rhythm and that circadian enhancers can restore antiviral defenses.

Train-the-Trainer as an Effective Approach to Building Global Networks of Experts in Genomic Surveillance of AMR

This paper describes a Train-the-Trainer program to build genomic surveillance capacity for AMR in LMICs, showing 40% of trainees initiated local capacity-building efforts after 6 months.

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

Joint antibiotic and phage therapy: addressing the limitations of a seemingly ideal phage for treating Staphylococcus aureus infections

This study evaluates the effectiveness of the phage PYOSa for treating Staphylococcus aureus infections, finding that while it has desirable traits, it fails to eliminate bacterial populations due to small colony variants, which can be mitigated by combining it with bactericidal antibiotics.

Primate phylogenomics uncovers multiple rapid radiations and ancient interspecific introgression

This study uses genome-wide data to resolve primate phylogenetic relationships, identifying multiple radiations and ancient introgression events.

From village to globe: A dynamic real-time map of African fields through PlantVillage

The paper describes a method for collecting high-quality ground truth data for African farms using youth in Kenya, providing real-time data linked to climate change impacts.

Missense mutations in the MLKL brace region lead to lethal neonatal inflammation in mice and are present in high frequency in humans.

This study identifies a missense mutation in MLKL causing lethal neonatal inflammation in mice and links it to increased frequency in human autoinflammatory disease.

Muramyl endopeptidase Spr contributes to intrinsic vancomycin resistance in Salmonella enterica serovar Typhimurium

This study shows that the muramyl endopeptidase Spr in Salmonella Typhimurium contributes to intrinsic vancomycin resistance without affecting outer membrane permeability.

Reproductive longevity predicts mutation rates in primates

The paper shows that paternal age determines de novo mutation rates in owl monkeys and proposes a model linking reproductive longevity to mutation rates across primates.

Functional constraints on replacing an essential gene with its ancient and modern homologs

This study replaces the essential tufA gene in E. coli with extant and ancestral homologs, showing that functional transfer depends on the presence of tufB and evolutionary distance.