A syntenin-deficient microenvironment educates AML for aggressiveness
R. Leblanc, J. Fares, A. Goubard, R. Castellano, L. Camoin, M. Balzano, R. Ghossoub, B. Bou-Tayet, C. Fauriat, N. Vey, J.-P. Borg, Y. Collette, M. Aurrand-Lions, G. David, P. Zimmermann
This study shows that syntenin-deficiency in the bone marrow microenvironment promotes AML aggressiveness by enhancing cell survival through autophagy and protein synthesis.
bioRxiv · Jan 6, 2021 · PreprintCancer Biology