The eukaryotic translation initiation factor eIF4E reprogrammes the splicing machinery anddrives alternative splicing
M. Ghram, G. Morris, B. Culjkovic-Kraljacic, J. C. Mars, P. Gendron, L. Skrabanek, M. V. Revuelta, L. Cerchietti, M. Guzman, K. Borden
This paper shows that eIF4E elevation reprograms splicing in AML, affecting thousands of transcripts and linking to poor prognosis, independent of splice factor mutations.
bioRxiv · Dec 7, 2021Cancer Biology