Author

B. D. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:deep learning· 2 Organism:human· 2 Assay:imaging· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

T. C. Shoyer· 2 shared A. D. Lynch· 1 shared A. Rancu· 1 shared A. S. LaCroix· 1 shared A. T. Blanchard· 1 shared A. Wax· 1 shared C. Gilchrist· 1 shared C. U. Chan· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersCell Biology

T. C. Shoyer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Detection of Fluorescent Protein Mechanical Switching in Cellulo

T. C. Shoyer, K. L. Collins, T. R. Ham, A. T. Blanchard, J. N. Malavade, J. L. West, B. D. Hoffman

This paper detects fluorescent protein mechanical switching in living cells using FRET-based biosensors and shows it is reversible and influenced by cellular forces.

bioRxiv · Jan 10, 2024Cell Biology

Analysis of intracellular transport dynamics using quantitative phase imaging and FRET-based calcium sensors

R. E. Highland, A. Rancu, H. Price, S. M. Parker, M. Reynolds, B. D. Hoffman, A. Wax

The paper combines quantitative phase imaging with FRET-based calcium sensors to study cellular responses to hypo-osmotic stimuli, revealing localized mass transport and calcium influx.

bioRxiv · May 5, 2023 · PreprintBiophysics

Coupling During Collective Cell Migration is Controlled by a Vinculin Mechanochemical Switch

T. C. Shoyer, E. M. Gates, J. I. Cabe, D. E. Conway, B. D. Hoffman

This study identifies a vinculin switch that regulates mechanical coupling during collective cell migration by controlling adhesion-based friction.

bioRxiv · Jan 13, 2023Cell Biology

Mechanically Induced Integrin Ligation Mediates Intracellular Calcium Signaling with Single Pulsating Cavitation Bubbles

F. Li, T. H. Park, G. Sankin, C. Gilchrist, D. Liao, C. U. Chan, Z. Mao, B. D. Hoffman, P. Zhong

This study investigates how mechanically induced integrin ligation via cavitation bubbles triggers intracellular calcium signaling in HEK293T cells, identifying P2X channels as key mediators.

bioRxiv · Oct 25, 2020Biophysics

Tunable molecular tension sensors reveal extension-based control of vinculin loading

A. S. LaCroix, A. D. Lynch, M. E. Berginski, B. D. Hoffman

This study develops tunable molecular tension sensors with improved functionality and uses them to show extension-based control of vinculin loading.

bioRxiv · Feb 12, 2018Biophysics