M. Reynolds

A SMART method for efficiently isolating monoclonal antibodies from individual rhesus macaque memory B cells

This paper introduces a SMART-based method to efficiently isolate monoclonal antibodies from individual rhesus macaque memory B cells, improving PCR efficiency and antibody recovery.

Analysis of intracellular transport dynamics using quantitative phase imaging and FRET-based calcium sensors

The paper combines quantitative phase imaging with FRET-based calcium sensors to study cellular responses to hypo-osmotic stimuli, revealing localized mass transport and calcium influx.

Regulatory network structure and environmental signals constrain transcription factor innovation

The paper shows that high expression levels, not protein homology, determine rewiring potential of transcription factors in Pseudomonas fluorescens.

Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation

This study shows CYB5R3 modulates NOX4 activity via coenzyme Q to reduce endothelial inflammation, with in vivo and in vitro evidence of their interaction and functional dependency.

Heme stimulates platelet mitochondrial oxidant production via the activation of toll-like receptor 4 signaling to mediate targeted granule secretion

This study shows that heme activates platelet TLR4 signaling, leading to mitochondrial ROS production and targeted granule secretion, with implications for thrombo-inflammatory responses.

Generation of SIV resistant T cells and Macrophages from Nonhuman Primate Induced Pluripotent Stem Cells with Edited CCR5 locus

This study generates CCR5-edited T cells and macrophages from nonhuman primate iPSCs, showing resistance to SIV replication.

Genotypic differences in wheat yield determinants within a NAM population based on elite parents

The paper evaluates genotypic differences in wheat yield determinants within a NAM population to identify stable beneficial trait combinations for improved grain yield.