Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor
C. H. Williams, L. R. Neitzel, P. Karki, T. E. Thayer, B. D. Keyesr, Q. S. Wells, J. A. Perry, K. Birukov, A. Birukova, C. C. Hong
This study identifies ogremorphin, a GPR68 inhibitor, and shows it reduces migration and invasion in melanoma cells, linking GPR68 proton-sensing to cancer metastasis.
bioRxiv · Jan 4, 2021 · PreprintCancer Biology