Author

J. A. Perry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

C. A. Hunter· 5 shared D. A. Christian· 4 shared J. T. Clark· 3 shared A. P. Hart· 2 shared A. S. Maddox· 2 shared J. Gullicksrud· 2 shared J. Park· 2 shared L. Shallberg· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersImmunology

C. A. Hunter

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Animal septins contain functional transmembrane domains

J. A. Perry, M. E. Werner, S. Omi, B. W. Heck, P. S. Maddox, M. Mavrakis, A. S. Maddox

The paper identifies a transmembrane domain in septins from C. elegans and primates, showing it is required for membrane association and tissue integrity.

bioRxiv · Nov 20, 2023Cell Biology

PD-1 and CTLA-4 exert additive control of effector regulatory T cells

J. A. Perry, Z. Lanzar, J. T. Clark, A. P. Hart, B. B. Douglas, L. Shallberg, K. O'Dea, D. A. Christian, C. A. Hunter

This study shows that PD-1 and CTLA-4 pathways additively regulate effector Treg cells by modulating their suppressive function and proliferation.

bioRxiv · Jul 22, 2022 · PreprintImmunology

Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis

L. A. Shallberg, A. T. Phan, D. A. Christian, J. A. Perry, B. E. Haskins, D. P. Beiting, T. H. Harris, A. A. Koshy, C. A. Hunter

This paper investigates how secondary TCR engagement affects CD8+ T cell heterogeneity during acute and chronic toxoplasmosis, showing its role in effector responses but limited impact on memory populations.

PLOS Pathogens · Jun 21, 2022Peer-reviewedImmunology

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

D. VanDyke, M. Iglesias, J. Tomala, A. Young, J. Smith, J. A. Perry, E. Gebara, A. R. Cross, L. S. Cheung, A. G. Dykema, B. T. Orcutt-Jahns, T. Henclova, J. Golias, J. Balolong, L. M. Tomasovic, , J. B. Spangler

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

bioRxiv · May 29, 2022Bioengineering

IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii

J. T. Clark, D. A. Christian, J. Gullicksrud, J. A. Perry, J. Park, M. Jacquet, J. C. Tarrant, E. Radaelli, J. Silver, C. A. Hunter

The paper shows IL-33 enhances ILC-mediated resistance to Toxoplasma gondii by promoting IFN-γ production and reducing parasite replication.

bioRxiv · Jan 10, 2021Immunology

Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor

C. H. Williams, L. R. Neitzel, P. Karki, T. E. Thayer, B. D. Keyesr, Q. S. Wells, J. A. Perry, K. Birukov, A. Birukova, C. C. Hong

This study identifies ogremorphin, a GPR68 inhibitor, and shows it reduces migration and invasion in melanoma cells, linking GPR68 proton-sensing to cancer metastasis.

bioRxiv · Jan 4, 2021 · PreprintCancer Biology

PD-L1 - PD-1 interactions limit effector Treg cell populations at homeostasis and during infection

J. A. Perry, J. T. Clark, J. Gullicksrud, J. DeLong, L. Shallberg, B. Douglas, A. P. Hart, C. Konradt, J. Park, A. Glatman Zaretsky, R. de Waal Malefyt, D. A. Christian, A. H. Sharpe, C. A. Hunter

This study shows that PD-L1-PD-1 interactions regulate Treg cell populations at homeostasis and during infection, limiting their numbers to enhance pathogen-specific CD4+ T cell responses.

bioRxiv · Dec 9, 2020 · PreprintImmunology

Septins and a formin have distinct functions in anaphase chiral cortical rotation in the C. eleganszygote.

A. Zaatri, J. A. Perry, A. S. Maddox

This study identifies distinct roles for septins and the formin CYK-1 in driving chiral cortical rotation during anaphase in C. elegans zygotes.

bioRxiv · Aug 7, 2020Cell Biology