Fatty acid oxidation drives hydrogen peroxide production by α-ketoglutarate dehydrogenase
C. Grayson, B. Faerman, O. Koufos, R. Mailloux
This study identifies α-ketoglutarate dehydrogenase (KGDH) as a major source of mitochondrial hydrogen peroxide (mH2O2) during fatty acid oxidation, showing sex-independent effects.
bioRxiv · Nov 23, 2023 · PreprintBiochemistry