Synovial macrophage activation mediates pain experiences in experimental knee osteoarthritis
G. Blackler, Y. Lai-Zhao, J. Klapak, H. T. Philpott, K. K. Pitchers, A. R. Maher, B. Fiset, L. A. Walsh, E. R. Gillies, C. T. Appleton
The study shows that targeting synovial macrophages via STAT6 inhibition reduces pain in experimental knee OA without worsening joint damage.
bioRxiv · Apr 25, 2023Physiology