MicrobiologybioRxiv
Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model
F. Siwczak, Z. Cseresnyes, S. Carlstedt…·A. Mosig
This study shows that S. aureus targets liver macrophages in a liver-on-chip model, with M2 polarization promoting bacterial persistence and small colony variant formation.
DOI 10.1016/j.biomaterials.2022.121632