The fitness cost of mismatch repair mutators in Saccharomyces cerevisiae: partitioning the mutational load
B. Galeota-Sprung, B. Guindon, P. Sniegowski
The paper estimates mutational load in mismatch repair-deficient yeast by partitioning it into nonlethal and lethal components using competitive fitness and lineage tracking experiments.
bioRxiv · Mar 16, 2020Evolutionary Biology