Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?
B. Gulave, D. Budda, M. A. Saleh, J. G. C. van Hasselt, E. C. M. de Lange
This study evaluates how nonlinear blood-brain barrier transport affects morphine and its metabolite pharmacokinetics in brain extracellular fluid across different dosing strategies using a simulation model.
bioRxiv · Mar 17, 2023 · PreprintPharmacology & Toxicology