Author

J. G. C. van Hasselt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Liakopoulos· 2 shared D. E. Rozen· 2 shared L. B. S. Aulin· 2 shared B. Gulave· 1 shared D. Budda· 1 shared E. C. M. de Lange· 1 shared E. Fragkiskou· 1 shared M. A. Saleh· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

A. Liakopoulos

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintMar 17, 2023

Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?

B. Gulave, D. Budda, M. A. Saleh…·E. C. M. de Lange

This study evaluates how nonlinear blood-brain barrier transport affects morphine and its metabolite pharmacokinetics in brain extracellular fluid across different dosing strategies using a simulation model.

DOI 10.1101/2023.03.17.533135

humanbulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologyNature CommunicationsPeer-reviewedSep 28, 2021

Design principles of collateral sensitivity-based dosing strategies

L. B. S. Aulin, A. Liakopoulos, P. H. van der Graaf…·J. G. C. van Hasselt

This study uses mathematical modeling to identify design principles for collateral sensitivity-based antibiotic treatment strategies that can suppress resistance.

DOI 10.1038/s41467-021-25927-3

statistical modeldrug response / drug discovery

𝕏 PostBluesky

MicrobiologybioRxivPreprintOct 19, 2020

Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone-resistance evolution

A. Liakopoulos, L. B. S. Aulin, M. Buffoni…·D. E. Rozen

The paper measures collateral and fitness effects of fluoroquinolone resistance alleles in Streptococcus pneumoniae and shows how allelic identity influences resistance evolution dynamics.

DOI 10.1101/2020.10.19.345058

humanstatistical model

𝕏 PostBluesky