Author

E. C. M. de Lange

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

B. Gulave· 1 shared D. Budda· 1 shared E. Vendel· 1 shared J. G. C. van Hasselt· 1 shared M. A. Saleh· 1 shared V. Rottschäfer· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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1 shared paperPharmacology & Toxicology

B. Gulave

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2 papers

Recent·Most cited

Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?

B. Gulave, D. Budda, M. A. Saleh, J. G. C. van Hasselt, E. C. M. de Lange

This study evaluates how nonlinear blood-brain barrier transport affects morphine and its metabolite pharmacokinetics in brain extracellular fluid across different dosing strategies using a simulation model.

bioRxiv · Mar 17, 2023 · PreprintPharmacology & Toxicology

A 3D brain unit model to further improve prediction of local drug distribution within the brain

E. Vendel, V. Rottschäfer, E. C. M. de Lange

This paper develops a 3D brain unit model to quantify how factors like blood flow, BBB transport, and drug binding affect local drug concentrations in brain extracellular fluid.

bioRxiv · Jul 1, 2019Pharmacology & Toxicology