Author

B. H. T. Ho

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Biochemistry· 1

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

B. A. Spicer· 1 shared C. Bayly-Jones· 1 shared C. J. Lupton· 1 shared C. Lau· 1 shared E. W. W. Leung· 1 shared H. Venugopal· 1 shared J. C. Whisstock· 1 shared L. D'Andrea· 1 shared

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2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

B. A. Spicer

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1 paper

Recent·Most cited

The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

C. Bayly-Jones, B. H. T. Ho, C. Lau, E. W. W. Leung, L. D'Andrea, C. J. Lupton, S. M. Ekkel, H. Venugopal, J. C. Whisstock, T. E. Mollnes, B. A. Spicer, M. A. Dunstone

This study identifies the discontinuous quaternary neoepitope of the C9 protein in the complement C5b-9 complex using cryo-EM, revealing its formation through adjacent domains without major conformational changes.

bioRxiv · Jul 6, 2022 · PreprintBiochemistry