C. Bayly-Jones

Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer

This study identifies a novel feed-forward signalling axis between PEAK1 and CAMK2 in TNBC, showing that targeting CAMK2 can inhibit PEAK1-driven oncogenic processes.

The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

This study identifies the discontinuous quaternary neoepitope of the C9 protein in the complement C5b-9 complex using cryo-EM, revealing its formation through adjacent domains without major conformational changes.

Helical ultrastructure of the oncogenic metalloprotease meprin α in complex with a small molecule hydroxamate inhibitor

This study determines the high-resolution structure of meprin α, revealing its helical assembly and interactions with an inhibitor and fetuin-B, showing oligomerization enhances stability without affecting activity.

Single-molecule analysis of the entire perfringolysin O poreformation pathway

This study uses single-molecule fluorescence imaging to analyze the kinetics of PFO pore formation, revealing that membrane insertion is kinetically controlled.

The cryo-EM structure of the neurofibromin dimer reveals the molecular basis for von Recklinghausen disease

This paper determines the cryo-EM structure of full-length NF1, revealing its autoinhibited conformation and providing insights into disease mechanisms and therapeutic strategies.

The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification.

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.